Adapalene API used for Topical treatment of acne vulgaris, including comedonal and inflammatory acne; helps reduce blackheads, whiteheads, papules, and pustules.
Key Properties:
- Chemical Name: 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid
- CAS Number: 106685-40-9
- Molecular Formula: C₂₈H₂₈O₃
- Molecular Weight: 412.53 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Practically insoluble in water; soluble in tetrahydrofuran (THF), acetone, and dimethyl sulfoxide (DMSO); slightly soluble in ethanol
- Mechanism of Action: Adapalene is a third-generation synthetic retinoid that selectively binds to retinoic acid receptors (RAR-β and RAR-γ). It modulates cellular differentiation, keratinization, and inflammatory processes, leading to normalization of follicular epithelial cell turnover and reduced comedone formation
- Bioavailability: Very low systemic bioavailability (<0.1%) following topical application
- Half-life: Approximately 17 hours (systemic elimination after topical use)
- Metabolism: Minimally absorbed systemically; metabolized in the liver mainly by oxidation and conjugation pathways; excreted primarily via bile
- Uses: Topical treatment of acne vulgaris, including comedonal and inflammatory acne; helps reduce blackheads, whiteheads, papules, and pustules
- Seller: Adapalene API Available at Vimara Enterprises.
