Apixaban API used for Prevention of stroke and systemic embolism in non-valvular atrial fibrillation Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) Prevention of venous thromboembolism (VTE) after orthopedic surgery
Key Properties:
- Chemical Name: 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS Number: 503612-47-3
- Molecular Formula: C₂₅H₂₅N₅O₄
- Molecular Weight: 459.50 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Slightly soluble in water; soluble in DMSO, methanol, and ethanol
- Mechanism of Action: Apixaban is a selective, direct Factor Xa inhibitor, preventing thrombin generation and thrombus formation without direct effect on existing thrombi
- Bioavailability: ~50% (oral)
- Half-life: ~12 hours
- Metabolism: Metabolized primarily via CYP3A4/5; minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2; excreted via renal (~25%) and fecal routes
- Uses: used for Prevention of stroke and systemic embolism in non-valvular atrial fibrillation Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) Prevention of venous thromboembolism (VTE) after orthopedic surgery
- Seller: API Available at Vimara Enterprises.
