Albendazole API used for Treatment of intestinal and tissue helminth infections, including neurocysticercosis, hydatid disease (echinococcosis), ascariasis, hookworm, strongyloidiasis, trichuriasis, enterobiasis, and mixed worm infestations.
Key Properties:
- Chemical Name: Methyl N-(6-propylthio-1H-benzimidazol-2-yl)carbamate
- CAS Number: 54965-21-8
- Molecular Formula: C₁₂H₁₅N₃O₂S
- Molecular Weight: 265.33 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Practically insoluble in water; soluble in dimethyl sulfoxide (DMSO); slightly soluble in methanol; insoluble in ethanol
- Mechanism of Action: Albendazole is a broad-spectrum anthelmintic agent that inhibits β-tubulin polymerization in helminths, disrupting microtubule formation, impairing glucose uptake, leading to depletion of glycogen stores and parasite death
- Bioavailability: Low oral bioavailability (approximately 5%); significantly increased when administered with fatty meals
- Half-life: Albendazole itself has a short half-life (~1–2 hours); its active metabolite albendazole sulfoxide has a half-life of approximately 8–12 hours
- Metabolism: Extensively metabolized in the liver to albendazole sulfoxide (active) and further to albendazole sulfone (inactive); primarily excreted via bile and urine
- Uses: Treatment of intestinal and tissue helminth infections, including neurocysticercosis, hydatid disease (echinococcosis), ascariasis, hookworm, strongyloidiasis, trichuriasis, enterobiasis, and mixed worm infestations.
- Seller: Albendazole API Available at Vimara Enterprises.
