Amlodipine Besylate API used for Treatment of hypertension, chronic stable angina, and vasospastic (Prinzmetal’s) angina; also used to reduce the risk of cardiovascular events.
Key Properties:
- Chemical Name: 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate
- CAS Number: 111470-99-6
- Molecular Formula: C₂₀H₂₅ClN₂O₅ · C₆H₆O₃S
- Molecular Weight: 567.05 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Slightly soluble in water; freely soluble in methanol; soluble in ethanol
- Mechanism of Action: Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in vasodilation and reduced blood pressure
- Bioavailability: Approximately 60–80% after oral administration
- Half-life: Approximately 30–50 hours
- Metabolism: Extensively metabolized in the liver, primarily by CYP3A4, to inactive metabolites; excreted via urine and feces
- Uses: Treatment of hypertension, chronic stable angina, and vasospastic (Prinzmetal’s) angina; also used to reduce the risk of cardiovascular events
- Seller: Amlodipine Besylate API Available at Vimara Enterprises.
