Artemether API used for Treatment of uncomplicated malaria, particularly Plasmodium falciparum; commonly used in artemisinin-based combination therapy (ACT) with lumefantrine
Key Properties:
- Chemical Name: (3R,5aS,6R,8aS,9R,10aR,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepine
- CAS Number: 71963-77-4
- Molecular Formula: C₁₆H₂₆O₅
- Molecular Weight: 298.37 g/mol
- Appearance: White or almost white crystalline powder
- Solubility: Practically insoluble in water; soluble in ethanol, acetone, and oils
- Mechanism of Action: Artemether is a lipophilic artemisinin derivative that generates free radicals within malaria parasites after cleavage of its endoperoxide bridge, resulting in rapid parasite death
- Bioavailability: Low to moderate oral bioavailability; absorption is improved when taken with fatty food
- Half-life: Artemether: ~1–3 hours
- Metabolism: Rapidly metabolized in the liver via CYP3A4 and CYP2B6 to the active metabolite dihydroartemisinin
- Uses: Treatment of uncomplicated malaria, particularly Plasmodium falciparum; commonly used in artemisinin-based combination therapy (ACT) with lumefantrine
- Seller – Artemether API Available at Vimara Enterprises
