Artesunate API used for Treatment of severe and uncomplicated malaria, particularly caused by Plasmodium falciparum; widely used in artemisinin-based combination therapies (ACTs)
Key Properties:
- Chemical Name: (3R,5aS,6R,8aS,9R,10aR,12aR)-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-yl hydrogen succinate
- CAS Number: 88495-63-0
- Molecular Formula: C₁₉H₂₈O₈
- Molecular Weight: 384.42 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Freely soluble in water; soluble in ethanol and acetone
- Mechanism of Action: Artesunate is a semi-synthetic artemisinin derivative that produces reactive oxygen radicals within malaria parasites by cleavage of its endoperoxide bridge, leading to rapid parasite death
- Bioavailability: Moderate oral bioavailability; rapidly converted in vivo to the active metabolite dihydroartemisinin (DHA)
- Half-life: Artesunate: ~0.5 hours
- Metabolism: Rapidly hydrolyzed to dihydroartemisinin (DHA) in plasma and liver; further metabolized via hepatic pathways
- Uses: Treatment of severe and uncomplicated malaria, particularly caused by Plasmodium falciparum; widely used in artemisinin-based combination therapies (ACTs)
- Seller – Artesunate API Available at Vimara Enterprises
