Rosuvastatin belongs to a group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, so this reduces the amount of cholesterol in the blood.
Key Properties:
- Chemical Name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid.
- CAS Number: 147098-20-2
- Molecular Formula: C44H54CaF2N6O12S2
- Molecular Weight: 1001.1 g/mol.
- Appearance: Rosuvastatin calcium API is generally a crystalline white to off white powder.
- Solubility: Rosuvastatin Calcium API is less soluble in water
- Mechanism of Action: Rosuvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol biosynthesis.
- Bioavailability: Rosuvastatin API has poor solubility in water and gastrointestinal fluids, which limits its absorption from the digestive tract.
- Half-life: The half-life of Rosuvastatin API is approximately 19 hours.
- Metabolism: Rosuvastatin API is not extensively metabolized
- Uses: Rosuvastatin Calcium API is commonly used to lower bad cholesterol levels (LDL-C) and fats (triglycerides) in the blood. It also increases good cholesterol levels (HDL). Improving your cholesterol levels helps decrease your risk of heart disease, stroke, and heart attack.
- Seller – Vimara Enterprises
