Tretinoin API used for Topical treatment of acne vulgaris and photoaged skin, Improvement of skin texture, pigmentation, and fine wrinkles
Key Properties:
- Chemical Name: (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
- CAS Number: 302-79-4
- Molecular Formula: C₂₀H₂₈O₂
- Molecular Weight: 300.44 g/mol
- Appearance: Yellow to orange crystalline powder
- Solubility: Practically insoluble in water; soluble in ethanol, acetone, chloroform, and dimethyl sulfoxide (DMSO)
- Mechanism of Action: Tretinoin is a retinoic acid derivative that binds to retinoic acid receptors (RARs), regulating gene transcription involved in cell differentiation and proliferation. In dermatology, it normalizes follicular epithelial desquamation and reduces comedone formation; in oncology, it induces differentiation of malignant promyelocytes
- Bioavailability: Topical use: very low systemic bioavailability (<2%)
- Half-life: Approximately 0.5–2 hours
- Metabolism: Extensively metabolized in the liver by CYP450 enzymes to inactive metabolites; excreted via bile and urine
- Uses: Topical treatment of acne vulgaris and photoaged skin, Improvement of skin texture, pigmentation, and fine wrinkles
- Seller: Tretinoin API Available at Vimara Enterprises.
